Tolerogenic Nanoparticles to Treat Islet Autoimmunity
نویسندگان
چکیده
منابع مشابه
Adaptive control: a strategy to treat autoimmunity.
Anti-idiotype of (natural) autoantibodies participate in the regulation of autoantibodies, their idiotypes. Focusing on an idiotype/anti-idiotype pair embedded in an environment such as the central immune system, we start with the experimental fact that the level of anti-idiotypes is low in autoimmune patients but high in healthy individuals, and present a quantitative model. This is then used ...
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There is an unexplained excess of type 1 diabetes and other organ-specific autoimmune diseases in children with Down's syndrome, but the immunogenetic characteristics of diabetes in Down's syndrome have not been investigated. We studied the frequency of islet autoantibodies in 106 children with Down's syndrome and no history of autoimmunity and analyzed HLA class II genotypes in 222 children wi...
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Plasmacytoid dendritic cells (pDCs) are a particular subset of DCs that link innate and adaptive immunity. They are responsible for the substantial production of type 1 interferon (IFN-I) in response to viral RNA or DNA through activation of TLR7 and 9. Furthermore, pDCs present antigens (Ag) and induce naïve T cell differentiation. It has been demonstrated that pDCs can induce immunogenic T ce...
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BACKGROUND Islet cell transplantation can cure type 1 diabetes (T1D), but only a minority of recipients remains insulin-independent in the following years. We tested the hypothesis that allograft rejection and recurrent autoimmunity contribute to this progressive loss of islet allograft function. METHODOLOGY/PRINCIPAL FINDINGS Twenty-one T1D patients received cultured islet cell grafts prepar...
متن کاملEarly Childhood Infections and the Risk of Islet Autoimmunity
OBJECTIVE Type 1 diabetes is a common chronic childhood disease, and the incidence is increasing globally. Childhood infections are considered a potential environmental trigger of type 1 diabetes. Alternatively, improved hygiene and reduced childhood infections could explain the increase in type 1 diabetes in developed countries. The association of reported illnesses during infancy and later de...
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ژورنال
عنوان ژورنال: Current Diabetes Reports
سال: 2017
ISSN: 1534-4827,1539-0829
DOI: 10.1007/s11892-017-0914-z